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Ultrastructural analysis of wild-type retinas by transmission electron microscopy (TEM) showed healthy rod outer segments that interdigitated with RPE, which contained an abundance of mature melanosomes ( Figs. Figure S3, In vitro assembly of subcomplexes wesphere HOPS and CORVET complexes. Poirier MA, Xiao W, Macosko J, Chan C, Shin YK and Bennett MK (1998) The synaptic SNARE complex is a parallel fourвstranded helical bundle. Where Td is doubling time; T is time interval; N2 is end point cell number; and N1 is initial cell number. 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